BEATTIE, Christopher,WADSWORTH, Anne,RENNIE, James
申请号：
ES13737828
公开号：
ES2627819T3
申请日:
2013.07.11
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of the formula: ** ** Formula wherein: R1, R2, R3 and R4 are selected from an electron-group, -NO2, -NH2, halogen or a substituent represented by the following formula ** ** Formula where and it can be in the ortho, meta or para position on the phenyl rings and is selected from hydrogen, hydrocarbyl, non-aromatic carbocyclic, non-aromatic heterocyclic, aryl, alkylaryl, arylalkyl or a hydrocarbyl group, non-aromatic carbocyclic, non-aromatic heterocyclic, aryl, alkylaryl or arylalkyl substituted with 1 a4 hydrophilic groups selected from hydroxy, alkoxy, -C (O) OR5, -SOR6, -SO2R6, nitro, amido, ureido, carbamate, -SR7, -NR8R9 or polyalkylene oxide or a substituent represented by the formula (3) as at least iempre unode R1, R2, R3 and R4 is the substituent represented by formula (2) wherein Y represents formula (3) is provided ** ** Formula wherein: X is selected from oxygen or sulfur R5, R6, R7, R8, R9, R10 and R11 are selected from hydrogen and C1 to C4 hydrocarbyl Z is a carborane group comprising at least two carbon atoms and at least three boron atoms, or at least one carbon atom and at least five boron atoms, within a cage structure r is 0 or an integer from 1 to 20 a represents an integer of 1 to 4 and it is also provided that at least one of R1, R2, R3 and R4 is an electron group -NO2, -NH2 or halogen and M is selected from two hydrogen ions, a monovalent single metal ion, two monovalent metal ions, a divalent metal ion, a metal ion trivalent metal ion tetravalent metal ion pentavalent or a metal ion hexavalent wherein the metal complex porphyrin derived from a monovalent simple metal ion is balanced load by a counter cation, and the porphyrin metal complex derived from a trivalent metal ion, tetravalent, pentavalent or hexavalent is balanced load by an appropriate number of counter anions, dianions, or trianions for use in the treatment of cancer by radiotherapy by administering a single dose of the compound with no more frequently than once every
