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Agents anti-inflammatoires
专利权人:
CAMBRIDGE ENTERPRISE LIMITED
发明人:
申请号:
EP06744244.2
公开号:
EP1896012B1
申请日:
2006.06.14
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The invention relates inter alia to a compound of general formula (I) or (I'): wherein z is 1,2 or 4; X is -CO-Y k -(R 1 ) n or SO 2 -Y k -(R 1 ) n ; k is 0 or 1; Y is a cycloalkyl or polycyloalkyl group (such as an adamantyl, adamantanemethyl, bicyclooctyl, cyclohexyl, cyclopropyl group); or is a cycloalkenyl or polycycloalkenyl group; each R 1 is independently selected from hydrogen or an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radical of 1 to 20 carbon atoms (for example of 5 to 20 carbon atoms, of 8 to 20 carbon atoms, of 9 to 20 carbon atoms, of 10 to 18 carbon atoms, of 12 to 18 carbon atoms, of 13 to 18 carbon atoms, of 14 to 18 carbon atoms, of 13 to 17 carbon atoms); or each R 1 is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl or aminodialkyl radical; and n is any integer from 1 to m, where m is the maximum number of substitutions permissible on the cyclo-group Y (such that n=1 if k=0, such that the R 1 group is bonded directly to the carbonyl or sulfonyl group); provided that simultaneously X cannot be an undec-10-en-1-oyl group and z be equal to 1 or 2; or alternatively R 1 is selected from a peptido radical having from 1 to 4 peptidic moieties linked together by peptide bonds.
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