It refers to a protein fused from formula (x) m - (R1) n - (y) O-B - (z) P,When x is senor cucumber, SEQ ID No.2; m is 0-1; R1 is amino acid; n is 0-6; a is Haemophilus influenzae type E, and is selected from the population composed of GG, GS, SS, etc.; O is 0-1; B is the accumulation of Haemophilus influenzae; Z is SEQ ID No.3;P is 0-1. The polyamide selected from the groups of SEQ ID No.136, SEQ ID No.138, SEQ ID No.140 and SEQ ID No.142 also involves the immune generation and vaccine development procedures.SE REFIERE A UNA PROTEINA DE FUSION DE LA FORMULA (X)m-(R1)n-A-(Y)o-B-(Z)p , DONDE X ES UN PEPTIDO SENAL, SEQ ID NO: 2; m ES 0-1; R1 ES UN AMINOACIDO; n ES 0-6; A ES LA PROTEINA E DE HAEMOPHILUS INFLUENZAE, Y SE SELECCIONA DEL GRUPO QUE CONSISTE EN GG, SG, SS, ENTRE OTROS; o ES 0-1; B ES PiLA DE HAEMOPHILUS INFLUENZAE; Z ES SEQ ID NO: 3 ; p ES 0-1. DICHA PROOTEINA DE FUSION SELECCIONADA DEL GRUPO QUE CONSISTE EN SEQ ID NO. 136, SEQ ID NO. 138, SEQ ID NO. 140, SEQ ID NO 142, ENTRE OTROS, SE REFIERE TAMBIEN A UNA COMPOSICION INMUNOGENICA Y A UN PROCEDIMIENTO PARA PREPARA UNA VACUNA.