Refers to a fusion protein of the formula (X) M - (R1) - N - (y) and (Z) - B - P, where X is a Signal Peptide, SEQ ID no: 2 M is 0 - 1 r1 is an amino acid n is 0 - 6 is the e Protein of Haemophilus influenzae, and is selected from the group consisting of GG, GS, SS, among others or is 0 - 1 b Cell has Emophilus influenzae Z is SEQ ID no: 2 p is 0 - 1.The prooteina Fusion is selected from the group consisting of SEQ ID no. 136, SEQ ID no. 138 SEQ ID no. 140, SEQ ID no 142, among others, also refers to an immunogenic Composition and to a process for preparing a vaccine.SE REFIERE A UNA PROTEINA DE FUSION DE LA FORMULA (X)m-(R1)n-A-(Y)o-B-(Z)p , DONDE X ES UN PEPTIDO SENAL, SEQ ID NO: 2 m ES 0-1 R1 ES UN AMINOACIDO n ES 0-6 A ES LA PROTEINA E DE HAEMOPHILUS INFLUENZAE, Y SE SELECCIONA DEL GRUPO QUE CONSISTE EN GG, SG, SS, ENTRE OTROS o ES 0-1 B ES PiLA DE HAEMOPHILUS INFLUENZAE Z ES SEQ ID NO: 3 p ES 0-1. DICHA PROOTEINA DE FUSION SELECCIONADA DEL GRUPO QUE CONSISTE EN SEQ ID NO. 136, SEQ ID NO. 138, SEQ ID NO. 140, SEQ ID NO 142, ENTRE OTROS, SE REFIERE TAMBIEN A UNA COMPOSICION INMUNOGENICA Y A UN PROCEDIMIENTO PARA PREPARA UNA VACUNA.
