PROBLEM TO BE SOLVED: To catalyze epimerization of sugar, which has few by-products, has low substrate specificity, and can catalyze epimerization of various sugars and / or has excellent heat resistance and is suitable for use on an industrial scale. Providing an enzyme that does The present invention provides an enzyme agent for a sugar epimerization catalyst, which comprises any one of the following proteins (a) to (c). (a) a protein comprising the amino acid sequence set forth in SEQ ID NO: 2； (b) an amino acid sequence having 90% or more amino acid sequence identity to the amino acid sequence set forth in SEQ ID NO: 2 and having a sugar epimerization activity A protein having: (c) a protein having an epimerization activity of sugar, which consists of an amino acid sequence in which one or several amino acids are substituted, inserted, deleted and / or added in the amino acid sequence of SEQ ID NO: 2. [Selection diagram] FIG.【課題】副生成物が少なく、基質特異性が低く様々な糖のエピメリ化を触媒することができ、および／または耐熱性に優れ工業的規模での利用に適した、糖のエピメリ化を触媒する酵素の提供すること。【解決手段】以下の(ａ)から(ｃ)のいずれか一のタンパク質を含む、糖のエピメリ化触媒用の酵素剤を提供する。(ａ) 配列番号２に記載のアミノ酸配列からなるタンパク質；(ｂ) 配列番号２に記載のアミノ酸配列に対して９０％以上のアミノ酸配列同一性を有するアミノ酸配列からなり、糖のエピメリ化活性を有するタンパク質；(ｃ) 配列番号２に記載のアミノ酸配列において、１もしくは数個のアミノ酸が置換、挿入、欠失および／または付加されたアミノ酸配列からなり、糖のエピメリ化活性を有するタンパク質。【選択図】図３
