ORTHO-MCNEIL PHARMACEUTICAL, INC.;JANSSEN PHARMACEUTICALS, INC.
发明人:
LU, TIANBAO,LAFRANCE, LOUIS,MARKOTAN, THOMAS,MARUGAN, JUAN JOSE,MARDER, VICTOR,U'PRICHARD, DAVID,ANACLERIO, BETH,GUO, ZIHONG,PAN, WENXI,LEONARD, KRISTI,TOMCZUK, BRUCE E.
申请号：
ES02709193
公开号：
ES2376161T3
申请日:
2002.01.29
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Compound having the formula IV in which: R1, R2, R3, R4 and R5 independently represent hydrogen, halogen, alkyl, aryl, aralkyl, heteroaryl or heteroarylalkyl； R6, R7, R8 and R9 independently represent hydrogen, alkyl, hydroxyalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, carboxyalkyl, aryl or aralkyl； or R6 and R7 are combined to form - (CH2) p-, where p is 2-8, while R8 and R9 are defined as before； or R8 and R9 are combined to form - (CH2) q-, where q is 2-8, while R6 and R7 are defined as before； or R6 and R8 are combined to form - (CH2) r-, where r is zero (a bond), 1 or 2, while R7 and R9 are defined as before； X represents oxygen, sulfur, -CH2-, -NH-, - (C = O) NH- or -NH (C = O) -； n is from 0 to 4； m is from 0 to 4； a is 0 or 1； D represents oxygen； v is 0 or 1； R10, R11, R12 and R13 independently represent: hydrogen； hydroxy； I rent； alkoxy； cycloalkyl； aryl, optionally substituted with one or more of halogen, hydroxy, cyano, alkyl, aryl, alkoxy, haloalkyl, arylalkyl, arylalkoxy, aryloxy, alkylsulfonyl, alkylsulfinyl, alkylalkoxyaryl, monoalkylamino, dialkylamino, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl； monoalkylamino； dialkylamino； aminoalkyl； monoalkylaminoalkyl； dialkylaminoalkyl； alkanoyl； heteroaryl having 5-14 ring members, optionally substituted with one or more of halogen, hydroxy, cyano, alkyl, aryl, alkoxy, haloalkyl, arylalkyl, arylalkoxy, aryloxy, alkylsulfonyl, alkylsulfinyl, alkylalkoxyaryl, monoalkylamino, dialkylamino, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, alkanoyl； or where R17 and R18 together form -CH2CH2-O-, -O-CH2CH2-, -O-CH2-O- or -O-CH2CH2-O-； or R10 and R12 are combined to form - (CH2) s-, where s is 0 (a bond) or 1 to 4, while R11 and R13 are as defined above； or R10 and R12 are combined to form a double bond when i is 0 and k is 1, while R11 and R13 are as defined above； or R10 and R11 are combined to form - (CH2) t, where t is 2 to 8, while R12 and R13 are as defined above, or R11 and R13 are
