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Aryloxy-N-bicyclomethyl-acetamide compounds substituted as VR1 antagonists
专利权人:
PFIZER; INC.
发明人:
INOUE, TADASHI,KAWASHIMA, TADASHI,NAGAYAMA, SATOSHI,SHISHIDO, YUJI
申请号:
ES06744787
公开号:
ES2382876T3
申请日:
2006.05.22
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound of the formula (I): in which A = B = D represents NR10-C (O) -NR9, SC (O) -NR9, NR9-C (O) -S, NR9-C (O) O , CR10-C (O) -NR9, OC (O) -NR9, NR10-C (O) -CR, NR10-NR9-C (O), C (O) -NR9-NR10, NR10-N = CR9, N = N-CR9, NR10-CR9 = N, N = CR9-NR10, NR10-N = N, N = N-NR10, S-CR9 = N or N = CR9-S; X1 represents CR1; X2 and X3 each independently represents CR8; R1, R6, R8, R9 and R10 each independently represents hydrogen, halogen, hydroxyl, (C1-C6) alkyl, (C1-C8) alkoxy, (C1-C6) hydroxyalkoxy, (C1-C6) alkoxy-(C1 -C6), (C1-C6) alkoxy (C1-C6) alkoxy, (C1-C6) haloalkyl (C1-C6) alkylthio (C1-C6) alkylsulfinyl or (C1-C6) alkylsulfonyl; R2, R3, R4, and R5 each independently represent hydrogen, (C1-C6) alkyl, halogen, halo (C1-C6) alkyl or hydroxy (C1-C6) alkyl; and R7 represents halogen, (C1-C6) alkyl, halo (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) hydroxyalkoxy, (C1-C6) alkoxy (C1-C8) alkyl, (C1 -C6) -C1-C6 alkoxy, [C1-C6 alkyl] NH- or [C1-C6 alkyl]] 2N-; or one of its pharmaceutically acceptable salts, with the proviso that: (i) when A = B = D represents NR10-N = N or N = N-NR10, then R2 represents (C1-C6) alkyl, halogen, haloalkyl ( C1-C6) or hydroxyalkyl (C1-C6); or (ii) when A = B = D represents NR10-N = N or N = N-NR10 and R2 represents (C1-C6) alkyl, then R7 represents halogen, (C1-C6) alkyl, (C1-C6) alkoxy , hydroxy (C1-C6) alkoxy, (C1-C6) alkoxy-(C1-C6) alkyl, (C1-C6) alkoxy (C1-C6) alkoxy, [(C1-C6) alkyl] NH- or [alkyl (C1-C6)] 2N-.Un compuesto de la fórmula (I) : en la que A=B=D representa NR10-C (O) -NR9, S-C (O) -NR9, NR9-C (O) -S, NR9-C (O) O, CR10-C (O) -NR9, O-C (O) -NR9, NR10-C (O) -CR, NR10-NR9-C (O), C (O) -NR9-NR10, NR10-N=CR9, N=N-CR9, NR10-CR9=N, N=CR9-NR10, NR10-N=N, N=N-NR10, S-CR9=N o N=CR9-S;X1 representa CR1; X2 y X3 representa cada uno independientemente CR8; R1, R6, R8, R9 y R10 representa cada uno independientemente hidrógeno, halógeno, hidroxilo, alquilo (C1-C6), alcoxilo (C1-C8), hidroxialcoxilo (C1-C6), alcoxi (C1-C6) -alquilo (C1-C6), alcoxi
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