2. Preparation and use as active drugs； 1. Claim 1: a formula compound (1),Where R1 represents an unorthodox or arillo group, where independent groups are not replaced, monkeys,di- or tri-substituted, wherein the substituents are independently selected from the group consisting of C₁₋₄ alkyl,C₃₋₆ cycloalkyl,C₁₋₄ alkoxy,Calcium fluoride c8321c83183323；Hydrogen fluoride c83218c83183323；hydroxy, halogen and phenoxy； R² represents heterocyclyl, which is unsubstituted, mono- or di-substituted, wherein the substituents are independently selected from C₁₋₄ alkyl,1. C83217c833183248a asphalt；C₁₋₄ alkoxycarbonyl,e. Keywords c83216c83318324 asphalt and halogen； isocyclic cyano； c83318326；which is unsubstituted or mono- or di-substituted with halogen； C₃₋₆ cycloalkyloxy；N-cycloalkyl C₃₋₆-amino； N-cycloalkyl C₃₋₆-methyl-amino； C₃₋₆ alkyl；C₂₋₆ alkoxy；N-Cila alkylamino；N, N-di- [C₁₋₄ alkyl] -amino； or N-arylmethyl-N-C₁₋₄-alkyl alkyl； R³ represents hydrogen or halogen； R⁴ represents hydrogen, fluoro, chloro, C₁₋₄ alkyl,C₁₋₄ alkoxy,C₁₋₄-carbonyl alkyl, hydroxy-C₁₋₄ alkyl,hydroxy C₂₋₄ alkoxy,C₁₋₂-C₁₋₄-alkoxy or C₁₋₄-C₂₋₄ alkoxy；R83099 stands for c832131 or 832431；and R⁶ represents fluoro, chloro, methyl, ethyl or C₁₋₂ fluoroalkyl；Or the salt of that compoundA su preparación y a su uso como compuestos farmacéuticamente activos. Reivindicación 1: Un compuesto de fórmula (1), en donde R¹ representa un grupo heteroarilo o arilo, donde los grupos están independientemente no sustituidos, mono-, di- o tri-sustituidos, en donde los sustituyentes están independientemente seleccionados del grupo que consiste en alquilo C₁₋₄, cicloalquilo C₃₋₆, alcoxi C₁₋₄, fluoroalquilo C₁₋₃, fluoroalcoxi C₁₋₃, hidroxi, halógeno y fenoxi； R² representa heterociclilo, el cual está insustituido, mono- o di-sustituido, en donde los sustituyentes se seleccionan independientemente de alquilo C₁₋₄, alquilcarbonilo C₁₋₄, alcoxicarbonilo C₁₋₄, alquilsulfonilo C₁₋₄ y halógeno； heterocicliloxi； cicloalquilo C₃₋₆, el cu
