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ПРОИЗВОДНОЕ ПУРИНОНА
专利权人:
发明人:
ЯМАМОТО Синго (JP),ЁСИЗАВА Тосио (JP)
申请号:
RU2012157072/04
公开号:
RU0002575340C2
申请日:
2011.05.30
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: compounds demonstrate metabolic stability and do not possess hepatotoxicity, that is are safe therapeutic medications for treating diseases, involving B-cells or mast cells. Compounds can be used in treatment of allergic disease, autoimmune disease, inflammatory disease, thromboembolic disease or cancer, in particular in treatment of non-Hodgkins lymphoma. In general formula (I) L represents (1) -O-, (5) -NH-, (6) -C(O)-, (7) -CH2-O-, (8) -O-CH2- or (9) -CH2- R1 represents (1) halogen atom, (2) C1-4alkyl group, (3) C1-4alkoxy group, or (4) C1-4halogenalkyl group cycle 1 represents cyclic group, selected from phenyl, C4-7cycloalkyl and pyridinyl, which can be substituted with 1-2 substituents, each of which is independently selected from the group, consisting of (1) halogen atoms, (2) C1-4alkyl groups, (3) C1-4alkoxy groups and (5) C1-4halogenalkyl groups, where in case of presence of two substituents in cycle 1 said substituents can form 4-7-membered cyclic group together with atoms in cycle 1, which said substituents are bound to, containing 2 oxygen atoms in cyclic group cycle 2 represents 4-7-membered nitrogen-containing saturated heterocycle, which has from one to two substituents -K-R2 K represents -C(O)- (where left bond is connected with cycle 2) R2 represents (2) C2-4alkenyl or (3) C2-4alkinyl group, each of which can be substituted with 1-2 substituents, each of which is independently selected from the group, consisting of (1) NR3R4, (2) halogen atoms, (3) CONR5R6, (4) CO2R7 and (5) OR8 each of R3 and R4 independently represents (1) hydrogen atom or (2) (2) C1-4alkyl group, which can have substituent OR9 or CONR10R11 R3 and R4 together with nitrogen atom, they are bound to, can form 4-7-membered nitrogen-containing saturated heterocycle, which contains nitrogen atom and, optionally, one more heteroatom, selected from nitrogen, sulphur and oxygen, which can be substituted with oxo group or hydroxyl group each of R5 and R6 indepe
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