OULMANN Kristofer (US),ОУЛМАНН Кристофер (US),PERNI Robert B. (US),ПЕРНИ Роберт Б. (US),VU Chi B. (US),ВУ Чи Б. (US),OULMANN KRISTOFER,ОУЛМАНН Кристофер,PERNI ROBERT B.,ПЕРНИ Роберт Б.,VU CHI B.,ВУ Чи Б.
申请号：
RU2011117159/04
公开号：
RU0002527269C2
申请日:
2009.09.29
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to novel chromenone derivatives of formula II or its pharmaceutically acceptable salts, where each R20 is hydrogen； R11 is selected from phenyl and 5-6 member saturated or aromatic heterocycle, including one or two heteroatoms, selected from N, O or S, where R11 is optionally substituted with one-two substituents, independently selected from C1-C4alkyl, =O, -O-R13, -(C1-C4alkyl)-N(R13)(R13), -N(R13)(R13), where each R13 is independently selected from hydrogen and -C1-C4alkyl； or two R13 together with nitrogen atom, to which they are bound, form 5-6-member saturated heterocycle, optionally including one additional O, where, when R13 is alkyl, alkyl is optionally substituted with one or more substituents, selected from -OH, fluorine, and, when two R13 together with nitrogen atom, to which they are bound, form 6-member saturated heterocycle, saturated heterocycle is optionally substituted on each carbon atom with -C1-C4alkyl； R12 is selected from phenyl and pyridyl, where R12 is optionally substituted with one or more substituents, independently selected from halogen, C1-C4alkyl, C1-C2 fluorine-substituted alkyl, -O-R13, -S(O)2-R13, -(C1-C4alkyl)-N(R13)(R13), -N(R13)(R13)； R14 is selected from hydrogen； and X1 is selected from -NH-C(=O)-†, -C(=O)-NH-†, - -S(=O)2-NH-†, where † stands for place, where X1 is bound with R11； and, when R14 is H； R12is phenyl； and X1 is - C(=O)-NH-†, then R11 is not 1H-pyrazol-3-yl, possessing stimulating activity.EFFECT: invention relates to pharmaceutical composition based on said compounds, method of treating subject, suffering from or having resistance to insulin, metabolic syndrome or diabetes, as well as to method of increasing sensitivity to insulin.16 cl, 1 tbl, 24 exИзобретение относится к новым производным хроменона формулы IIили его фармацевтически приемлемым солям, где каждый R20 является водородом； R11 выбирают из фенила и 5-6-членного насыщенного или ароматического
