Charles A. BLUM,Richard Dana CALDWELL,Rebecca CASAUBON,Jeremy S. DISCH,Ryan Michael FOX,Karsten KOPPETSCH,William Henry MILLER,Pui Yee NG,Christopher OALMANN,Robert B. PERNI,Bruce G. SZCZEPANKIEWICZ,B
申请号：
US15528195
公开号：
US20170355697A1
申请日:
2015.11.19
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to novel substituted bridged urea compounds, corresponding related analogs, pharmaceutical compositions and methods of use thereof. Sirtuin-modulating compounds of the present invention may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. The present invention also related to compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
