TRIVEDI, Naimisha,BAKER-GLENN, Charles,VAN DE POEL, Herve,ARMANI, Elisabetta,BLACKABY, Wesley,CAPALDI, Carmelida,AMARI, Gabriele,LINNEY, Ian
申请号：
PE2016002520
公开号：
PE20161557A1
申请日:
2015.06.03
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
It refers to a formula compound, wherein: R1 is hydrogen, halogen, C1-C4 tar, etc.； R2 is hydrogen, halogen, C1-C4 tar, etc.； m and N are 1-3； R3 and R4 are independent H (C3-C7) cyclopropane, among others； R5 is CN, NO2, CF3 or halide； K is 0, 2 or 3； x'es 0 or 1； R6 is carbon, C4. Among other things, R7 is an optional C1-C4 hydrocarbon； L is a u-ch2 -；L1 is an alliance, P is 1-4, L2 is an alliance； - (CH2) q is 1 or 2, W1 is arilino, heterocyclic or heterocyclic propene, W2 is arilo or heterocyclic, a is a group containing nitrogen, such as - (CH2) s-n8r9: s 1-4, R8 and R9 are hydrocarbon groups of C1-C4； Or a saturated alien ring system monkey, Bi or alternative tricycle. The most popular compounds are: 5 - [[1-methyl-2-oxo-1-phenyl-2 - [(3R) - quinuclin-3-il] oxi ethil] amine] methyl] thiophene-2-thyroid acid [(1s) - 2 - (3,5-dichloro-1-oxide-pyridine-1-io-4-il) - 1 - (3,4-methoxyphenyl) ethyl]；4 - [[1-methyl-2-oxo-1-phenyl-2 - [(3R) - quinuclin-3-il] o-ethyl] amino] methyl] benzoic acid [(1s) - 2 - (3,5-dichloro-1-dioxo-pyridine-1-io-4-il) - 1 - (3,4-dimethoxyphenyl) ethyl]； and so on. He also mentioned a pharmaceutical composer These compounds are inhibitors of phosphotetrase (PDE4) and antagonists of M3 muscle receptors, which are useful in the treatment of EPOC.Se refiere a compuestos de formula I, donde: R1 es hidrogeno, halogeno, alquilo C1-C4, entre otros； R2 es hidrogeno, halogeno, alquilo C1-C4, entre otros； m y n son 1 a 3； R3 y R4 son independientemente H, (C3-C7) cicloalquilcarbonilo, entre otros； R5 es CN, NO2, CF3 o halogeno； k es 0, 1, 2 o 3； x' es 0 o 1； R6 es alquilo C1-C4, alcoxi C1-C4, entre otros； R7 es hidrogeno o alquilo C1-C4 opcionalmente sustituido； L es una union o –CH2-； L1 es una union o –(CH2)p- donde p es 1 a 4； L2 es una union； -(CH2)q- donde q es 1 o 2； entre otros； W1 es arileno, heteroarileno o heterocicloalquileno； W2 es arilo o heteroarilo； A es un grupo que contiene nitrogeno tal como –(CH2)s-NR8R9 donde: s es 1 a 4, R8 y R
