BRUNNER, DANIELA,MALBERG, JESSICA,SHANKAR, BAVANI G.,KOLCZEWSKI, SABINE,LIMBERG, ANJA,PRINSSEN, ERIC,RIEMER, CLAUS,STOLL, THEODOR
申请号：
PE0003652015
公开号：
PE09432015A1
申请日:
2013.09.10
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
Referring to Derivatives of 2 - oxo - 2.3 - dihidroindoles of General formula (i), where N1 is pirimidinilo pyridinyl, phenyl, or imidazolilo, isoxazolilo pirazolilo n2 is phenyl or pyridinyl r1 is Hydrogen, alkyl C1 - C7 C1 - C7 replaced by alkyl, halogen, alkoxy C1 - C7 or Halogen n is 1 or 2 r1 R2 is alkyl and C1 - C7 or along with the carbon Atom to which they are attached,Cycloalkyl Ring form a C3 - 6 R3 is C1 - C7 cycloalkyl alkyl, cycloalkyl - CH2 - 6 C3, C3 C3 - 6 - 6, cycloalkyl, among others R4 is Hydrogen, halogen or alkyl of C1 - C7 M is 1 or 2.These compounds are useful in the treatment of central nervous system Disorders such as Substance Abuse, Alcohol and Drug Addiction, obsessive-compulsive disorders, Cognitive imbalance, among othersReferida a derivados de 2-oxo-2,3-dihidroindoles de la formula general (I), donde N1 es fenilo, piridinilo, pirimidinilo, imidazolilo, isoxazolilo o pirazolilo N2 es fenilo o piridinilo R1 es hidrogeno, alquilo C1-C7, alquilo C1-C7 sustituido por halogeno, alcoxi C1-C7 o halogeno n es 1 o 2 R1 y R2 son alquilo C1-C7 o junto con el atomo de carbono, al que estan unidos, forman un anillo cicloalquilo C3-6 R3 es alquilo C1-C7, cicloalquilo C3-6, CH2-cicloalquilo C3-6, cicloalquilo C3-6, entre otros R4 es hidrogeno, halogeno o alquilo C1-C7 m es 1 o 2. Dichos compuestos son utiles en el tratamiento de trastornos del sistema nervioso central tales como el abuso de sustancias, adiccion al alcohol y drogas, trastornos obsesivos-compulsivos, desequilibrio cognitivo, entre otros
