There is provided a CRF receptor antagonist comprising a compound of the formula (I) : A-W-Ar wherein, A is a group represented by the formula (A2), wherein ring Ab is a 5- or 6- membered ring which may be further substituted in addition to R1 ring Ac is a 5- or 6- membered ring which may be substituted R1 is an optionally substituted hydrocarbyl, a substituted amino, an optionally substituted cyclic amino, a substituted hydroxy, a substituted sulfanyl, an optionally substituted sulfinyl, or an optionally substituted sulfonylX is carbonyl, -O-, -S-, -SO-, or -SO2- Y1, Y2 and Q are independently optionally substituted carbon or nitrogen ... is a single or double bond W is a bond, an optionally substituted methylene, an optionally substituted ethylene, an optionally substituted imino, -O-, -S-, -SO-, or -SO2- Ar is an optionally substituted aryl or an optionally substituted heteroaryl or a salt thereof or a prodrug thereof.
