ZHU, YUN-FEI,CHEN, CHEN,TUCCI, FABIO C.,GUO, ZHIQIANG,GROSS, TIMOTHY D.,ROWBOTTOM, MARTIN,STRUTHERS, R. SCOTT
申请号：
ES01910362
公开号：
ES2383954T3
申请日:
2001.01.25
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound having the following structure: or one of its stereoisomers, prodrugs or pharmaceutically acceptable salts, wherein: Q is a direct bond； A is O, S or NR7； n is 2, 3 or 4； R1 and R2 are the same or different and are, independently, hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocycloalkyl, substituted heterocycloalkyl, -C (R1a) (>； = NR1b ) or -C (NR1aR1c) (>； = NR1b)； or R1 and R2, taken together with the nitrogen atom to which they are attached, form a heterocyclic ring or a substituted heterocyclic ring； R3a and R3b are the same or different and, at each occurrence, are, independently, hydrogen, alkyl, substituted alkyl, alkoxy, alkylthio, alkylamino, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocycloalkyl, heterocycloalkyl substituted, -COOR14 or -CONR14R15； or R3a and R3b, taken together with the carbon atom to which they are attached, form a homocyclic ring, substituted homocyclic ring, heterocyclic ring or substituted heterocyclic ring； or R3a and R3b, taken together, form>； = NR3c； or R3a and the carbon to which it is attached taken together with R1 and the nitrogen to which it is attached form a heterocyclic ring or substituted heterocyclic ring； R4 is substituted aryl or heterocycle； R5 is hydrogen, halogen, lower alkyl, substituted lower alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, alkoxy, alkylthio, alkylamino, cyano or nitro； R 6 is higher alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl； R7 is hydrogen, -SO2R11, cyano, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl； and R1a, R1b, R1c, R3c, R8a, R8b, R9, R9a, R10a, R10b, R11, R12, R13, R14
