CORTE, James R.,DE LUCCA, Indawati,FANG, Tianan,YANG, Wu,WANG, Yufeng,DILGER, Andrew K.,PABBISETTY, Kumar Balashanmuga,EWING, William R.,ZHU, Yeheng,WEXLER, Ruth R.,PINTO, Donald J. P.,ORWAT, Michael
申请号：
ES15705860
公开号：
ES2687498T3
申请日:
2015.01.30
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of Formula (I): ** Formula ** or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof, wherein: ring A is independently selected from a 6-membered aryl and a 5 to 5-heterocyclyl. 6 members, wherein said aryl and said heterocyclyl are optionally substituted with, where valence permits, one or more R4； Ring B is a 5-10 membered heterocyclyl optionally substituted with, where valence permits, one or more R3 or a 5-10 membered heterocyclyl comprising carbon atoms and 1-4 heteroatoms selected from N, NR3c , O, and S (O) py optionally substituted with, where valence permits, one or more R3； G1 is independently selected from C3-10 carbocyclyl and 5-10 membered heterocyclyl, wherein said carbocyclyl and said heterocyclyl are optionally substituted with, where valence permits, one or more R8； X is independently selected from C4-8 alkylene and C4-8 alkenylene, wherein said alkylene and said alkenylene are substituted with R1 and R2； alternatively one or more of the carbon atoms of said alkylene and said alkenylene can be substituted with O, C>； = O, S (>； = O) p, S (>； = O) pNH and NR15； Y is independently selected from -CR13NH-, -NHC (>； = O) -, -C (>； = O) NH-, -S (>； = O) pNH-, -NHS (>； = O) p- and alkylene C1-2； R1 and R2 are independently selected from H, D, halogen, haloalkyl, C1-6 alkyl (optionally substituted with R6), hydroxyl, and alkoxy optionally substituted with R6, and C3-6 cycloalkyl optionally substituted with R6； optionally, when R1 and R2 are attached to the same carbon atom, together they form a C3-6 oxo or cycloalkyl group； optionally, when R1 and R2 are attached to carbon atoms adjacent to each other, together they form a bond or a carbocyclyl； optionally, R1 and R15 or R2 and R15 taken together, form a ring； R3 is independently selected from H, NO2,>； = O, halogen, haloalkyl, C1-4 alkyl (optionally substituted with R6), C2-4 alkenyl (optionally substituted with R6), C2-4 alkynyl (optionally substituted with R6
