SHAH, Shrenik,ALI, Amjad,LO, Michael Man-Chu,WHITEHEAD, Brent,HENDERSON, Timothy,YAN, Lin,GUO, Zhiqiang
申请号：
ES12709453
公开号：
ES2627841T3
申请日:
2012.03.05
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound having the formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, in which X is O or NR7； ** Formula ** is attached to any carbon atom of the ring other than the carbon to which they are joined R1 and R2； R1 is hydrogen, -C (O) C1-6alkyl or -C (O) OH, or together with R2, form>； = O； R2 is hydrogen, or together with R1, form>； = O； R4 is -C1-6 alkyl, -CD2C1-5 alkyl, -C2-5 alkyl-OH, -C2-5-OC (O) C1-6 alkyl, -C1-6-aryl alkylene or -CH2CH>； = CH2 ； R5 and R6, which are attached to any available carbon ring atom, are independently hydrogen, deuterium, -C 1-6 alkyl, -C (O) C 1-6 alkyl, -C (O) OH, aryl, or R5 and R6, when attached to the same carbon atom, form together>； = O； R7 is hydrogen, -C 1-6 alkyl, -C 1-6 alkylene-aryl, -C 1-6C alkylene (O) O-C 1-6 alkyl, -C 1-6 alkylene-CR8R9R10, -CN, -C (O) O -C1-6 alkyl, -C (O) O-C1-6 alkylene CR8R9R10, -C (O) C1-6 alkyl, -C (O) C3-6 Ocarbocycle, -C (O) CHF2, -C (O ) CF3, -C (O) CH2OH, -C (O) aryl, -C (O) heteroaryl, wherein the heteroaryl is a 5 or 6 membered unsaturated ring having 1-4 heteroatoms selected from N, O and S , -C (O) C1-6 alkylene-OH, -C (O) C3-6 carbocycle, -C (O) NH2, -C (O) NH C1-6alkyl, -C (O) NH-adamantyl, - C (O) heterocycle, wherein the heterocycle is a 5 to 8 membered monocyclic saturated ring that has 1-4 heteroatoms selected from N, O and S, or a 7 to 12 membered saturated bicyclic ring system that has 1- 6 heteroatoms selected from N, O and S, -C (O) C3-6 NHcarbocycle, -C (O) N (C1-6 alkyl) C1-6 alkyl, -C (O) NHSO2aryl, -SO C1-6 alkyl, -SO2 C1-6 alkyl, -SO2NH (C1-6 alkyl), -SO2N (C1-6 alkyl) (C1-6 alkyl), -SO2CF3； -SO2aryl, -SO2heteroaryl, wherein the heteroaryl is a 5 or 6 membered unsaturated ring having 1-4 heteroatoms selected from N, O and S, aryl, a 5 or 6 membered unsaturated heteroaryl ring having 1-4 heteroatoms selected from N, O and S, or -C3-6 carbocycle； wherein the aryl, alkyl, alkylene, carbocycle, heteroaryl and heterocycle are unsubstituted or substi
