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URAT1抑制劑
专利权人:
J-PHARMA CO., LTD.;DETHREE RES. LAB. INC.;NIPPON CHEMIPHAR CO., LTD.
发明人:
ENDO, TSUYOSHI,远藤刚,遠藤剛,KOBAYASHI, KUNIO,小林邦夫,TANAKA, HIROTO,田中人,SAITO, DAISUKE,齐藤大佑,齊藤大祐,HIRANO, MASUHARU,平野益治,ENDOU, HITOSHI,远藤仁,遠藤仁,ANZAI, NAOHIKO,安西尚彦
申请号:
TW104144182
公开号:
TW201632499A
申请日:
2015.12.29
申请国别(地区):
TW
年份:
2016
代理人:
摘要:
The present invention relates to a compound represented by following general formula (III), the compound’ s tautomer, stereomer, or pharmaceutical accpetable salts, or solvate thereof , as a treating agent for gout or hyperuricemia. (wherein, R1a, R2a, R6a and R7a represent a hydrogen atom, an alkyl having carbon numbers of 1~8, an alkoxy having carbon number 1~8, cyame and the like, R3a and R8a together with the 2 carbon atoms to which R3a and R8a are bonded form a benzene ring or a 5-membered heteroaryl ring containing 1~3 hetero atoms selected from nitrogen atom, oxygen atom or sulfur atom, R4a and R5a together with the 2 carbon atoms to which R4a and R5a are bonded form a benzene ring, or have the same meaning as the above R1a, Xa represents an oxygen atom or a sulfur atom and the like, Ya represents an alkylene chain having a carbon numbers of 1~8, wherein, the alkylene chain may be a linear alkylene chain or a branched alkylene chain, and the branched alkylene chain may form a 3-~7-membered ring by combining the side chains which are bonded to the same or different carbon atoms, together with the carbon atom bonded thereto, and may have double bond existing within the chain, Za represents CO2H and the like.)本發明係有關將下述通式(III)表示之化合物、該化合物之互變異構物、立體異構物、或其藥學上容許之鹽或該等之溶劑化物作為痛風或高尿酸血症治療藥使用。(式中,R1a、R2a、R6a及R7a表示氫原子、碳數1至8之烷基、碳數1至8之烷氧基、氰基等,R3a及R8a為與R3a及R8a所結合之2個碳原子一同形成苯環或形成含有將選自氮原子、氧原子及硫原子之1至3個雜原子作為環構成元素之5員環雜芳環,R4a及R5a為與R4a及R5a所結合之2個碳原子一同形成苯環,或與上述R1a相同者,Wa表示CR10a或N,此處,R10a表示與上述R1a相同者,Xa表示氧原子或硫原子等,Ya表示碳數1至8之伸烷基鏈,此處,該伸烷基鏈可經碳數1至8之烷基等取代,又,該伸烷基鏈可為直鏈伸烷基鏈,亦可為支鏈伸烷基鏈,支鏈伸烷基鏈為結合於相同或不同碳原子之側鏈可與該等結合之碳原子一同形成3至7員環,另,可在其中間具有雙鍵,Za表示CO2H等)。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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