ALLAN Emi (US),АЛЛАН Эми (US),BRANSTETTER Brajan (US),БРАНСТЕТТЕР Брайан (US),DIK Brajan (US),ДИК Брайан (US),VAJNKHAUS Majkl I. (US),ВАЙНХАУС Майкл И. (US),GOMEZ Loran (US),ГОМЕЗ Лоран (US),MERRON Te,ALLAN Emi,АЛЛАН Эми,BRANSTETTER Brajan,БРАНСТЕТТЕР Брайан,DIK Brajan,ДИК Брайан,VAJNKHAUS Majkl I.,ВАЙНХАУС Майкл И.,GOMEZ Loran,ГОМЕЗ Лоран,MERRON Temi Dzho,МЭРРОН Тэми Джо,PITERS Marko,ПИТЕРС Марко
申请号：
RU2015100213
公开号：
RU0002653054C2
申请日:
2013.06.18
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: pharmacology.SUBSTANCE: invention relates to a compound of formula I in which each of Y and Z independently represents -CH- or -N-, with the proviso that at least one substituent Y or Z is -N-； M is 0-5； each of R1 is independently selected from H, halogen, -CN, -C1-6alkyl, -C1-6alkynyl-C1-6haloalkyl, -C1-6thioalkyl, -C1-6thiogaloalkyl, -C1-6alkoxy, -C1-6haloalkoxy, -SO2C1-6alkyl, aryl, pyrazole and 2-oxopyrrolidine； or two R1 substituents are on adjacent carbon atoms and (together with the carbon atoms to which they are attached) form a 5-6 membered saturated or unsaturated monocyclic ring system containing 2 oxygen or nitrogen atoms, wherein the said ring system is optionally substituted by -C1-6alkyl； each of R3 and R4 is independently selected from the group consisting of H, halogen, -C1-6alkyl substituted by one or two groups independently selected from -C1-6alkoxy, -C1-6alkoxy-C1-6alkoxy, and -OH； -C1-6haloalkyl substituted by -OH, -C1-6alkenyl of optionally substituted -C1-6alkoxy, -CH2O-phenyl, -C(O)CH3, -CH(OH)(CF3), -(CR10R11)0-3NR12R13, phenyl, and 6-membered heteroaryl having 1 to 2 heteroatoms selected from N, wherein each phenyl and heteroaryl are substituted by one or two moieties, each independently selected from the group consisting of -CH3, -OCH3, and oxo； each of R10 and R11 is independently selected from the group consisting of: -H, -F, -CF3, and OH； each of R12 and R13 is independently selected from the group consisting of -H, -C1-6alkyl optionally substituted by -C1-6alkoxy, N(C1-6alkyl)2； -CO2-benzyl； -C1-6alkyl(phenyl), -C1-6alkyl(4 to 5-membered heterocycloalkyl having 1 heteroatom selected from O), phenyl optionally substituted by -C1-6alkyl； -C1-6cycloalkyl optionally substituted by amino； 6-membered heterocycloalkyl having 1 heteroatom selected from N, O, optionally substituted -C1-6alkyl； or R12 and R13, taken together with the nitrogen atom to which they are attached, form a heterocycloalkyl. The invention also relates to indivi
