CID-NUNEZ, JOSÉ MARÍA,TRABANCO-SUAREZ, ANDRÉS AVELINO,VEGA RAMIRO, JUAN ANTONIO,OEHLRICH, DANIEL,TRESADERN, GARY JOHN,MACDONALD, GREGOR JAMES
申请号：
ES11779667
公开号：
ES2552879T3
申请日:
2011.11.08
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (I) ** Formula ** or a stereochemically isomeric form thereof, wherein R 1 is selected from the group consisting of C 1-6 alkyl, (C 3-8 cycloalkyl) C 1-3 alkyl, (alkyloxy C1-3) C1-3 alkyl and C1-3 alkyl substituted with 1, 2 or 3 fluoro substituents； R2 is selected from the group consisting of Cl, CF3, -CN and cyclopropyl； R3 is selected from the group consisting of hydrogen, methyl and CF3； R4 is selected from the group consisting of hydrogen and methyl； or R3 and R4 together with the carbon to which they are attached form a cyclopropyl ring or a carbonyl group； L is selected from the group consisting of (La), (Lb), (Ld), (Lc), (Le), (Lf), (Lh) and (Lg): ** Formula ** (Le) ( Lf) (Lg) (Lh) in which R5a, R5b, R5c and R5d are each independently selected from the group consisting of phenyl； phenyl substituted with 1 or 2 substituents each independently selected from the group consisting of C1-3 alkyloxy and halo； pyridinyl； pyridinyl substituted with 1 or 2 substituents each independently selected from the group consisting of C1-3 alkyl, C1-3 alkyloxy and halo； pyrimidinyl and pyrimidinyl substituted with 1 or 2 substituents each independently selected from the group consisting of C1-3 alkyl, C1-3 alkyloxy and halo； R6e is selected from the group consisting of hydrogen and C1-3 alkyl； R5f, R5g, and R5h are each independently selected from phenyl and phenyl substituted with 1 or 2 fluoro substituents； R6a, R6b and R6c are each independently selected from the group consisting of hydrogen； fluoro； C1-3 alkyl； C1-3 alkyl substituted with 1, 2 or 3 fluoro substituents； C1-3 alkyloxy； C1-3 alkyloxy substituted with 1, 2 or 3 fluoro substituents； and C3-6 cycloalkyl； R6h is C1-3 alkyl； R7a, R8a, R7b, R8b, R7c, R8c, R7d and R8d are each independently selected from the group consisting of hydrogen, halo and methyl； or each R7a and R8a, R7b and R8b, R7c and R8c, and R7d and R8d together with the carbon to which they are attached form a cyclopropyl or carbon
