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Composition antifongique avec une biodisponibilité améliorée
专利权人:
Schering Corporation
发明人:
申请号:
EP09158184.3
公开号:
EP2090165A3
申请日:
2002.04.01
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The invention provides a liquid suspension comprising an antifungally effective amount of the micronized compound represented by the chemical structural formula I:at least one thickening agent, at least one non-ionic surfactant, and a pharmaceutically acceptable liquid carrier.The invention also provides a dosing unit comprising the compound of chemical structural Formula I for use as a medicament, wherein the compound of chemical structural Formula I is micronized to a mean particle size of 1000 nm to 1800 nm, and the dosing unit comprises at least one thickening agent, at least one non-ionic surfactant, and a pharmaceutically acceptable liquid carrier, and comprises the compound of chemical structural formula I in an amount of 200 mg per 5 ml dose.The invention also provides a method of making a suspension of the micronized compound of chemical structural Formula I employing the following ingredients:IngredientConcentration Range(mg/ml)Coumpound of Formula I (micronized)10-100Polysorbate 805-50Sodium Citrate0.4-0.8Citric Acid0.36-0.6Simethicone2-4Xanthan Gum1-5Sodium Benzoate0.5-3Liquid Glucose200-500Glycerin50-150Artificial Cherry Flavor2-10Titanium Dioxide2-6Purified Waterwherein water, 40% of the polysorbate 80 and 40% of the simethicone are mixed, water is added, the compound of Formula I is added, and the mixture is micronized; water and the remainder of polysorbate 80 and simethicone are added and mixed; sodium benzoate, sodium citrate, citric acid and xanthan gum are added and mixed; glycerin is added and mixed; liquid glucose is added and mixed; titanium dioxide is added and mixed; artificial cherry flavor is added and mixed; and the remaining water to final volume is added and mixed.
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