4R,5S-ENANTIOMER 2-(5-METIL-2-OKSO-4-FENIL-PIROLIDIN-1-IL)-ACETAMIDA S NOOTROPSKIM DJELOVANJEM

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专利权人:

GRINDEKS; A JOINT STOCK COMPANY

发明人:

KALVINS, IVARS,LEBEDEVS, ANTONS,CERNOBROVIJS, ALEKSANDRS,DAMBROVA, MAIJA,ZVEJNIECE, LIGA,VORONA, MAKSIMS,VEINBERGS, GRIGORIJS

申请号：

HRP20131086

公开号：

HRP20131086T1

申请日:

2013.11.13

申请国别(地区):

HR

年份:

2013

代理人:

摘要：

The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrolidin-2-one, its N-alkylation with ethyl haloacetate and the treatment of intermediate ethyl 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetate with ammonia.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/