4R, 5S ENANTIOMES OF 2- (5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL) -ACETAMIDE WITH NOOTROPIC ACTIVITY

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专利权人:

GRINDEKS; A JOINT STOCK COMPANY

发明人:

KALVINS, IVARS,LEBEDEVS, ANTONS,CERNOBROVIJS, ALEKSANDRS,DAMBROVA, MAIJA,ZVEJNIECE, LIGA,VORONA, MAKSIMS,VEINBERGS, GRIGORIJS

申请号：

DK10776339

公开号：

DK2496555T3

申请日:

2010.11.04

申请国别(地区):

DK

年份:

2013

代理人:

摘要：

The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrolidin-2-one, its N-alkylation with ethyl haloacetate and the treatment of intermediate ethyl 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetate with ammonia.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/