The invention discloses a method for producing a hemostatic composition comprising mixing a biocompatible polymer suitable for use in hemostasis and a genipin-type crosslinker, crosslinking said polymer by said genipin-type crosslinker to obtain a crosslinked biocompatible polymer, and finishing said crosslinked polymer to a pharmaceutically acceptable hemostatic composition, new hemostatic compositions and methods for using such compositions.本發明揭示一種用於製造止血組成物之方法,其包含混合適用於止血之生物相容性聚合物與京尼平型交聯劑,藉由該京尼平型交聯劑交聯該聚合物以獲得經交聯之生物相容性聚合物,及將該經交聯聚合物最終加工成醫藥學上可接受之止血組成物;新穎止血組成物;及使用此等組成物之方法。