The present invention provides engineering calcitonin gene-related peptide (CGRP) antibody of people or its antigen-binding fragments. In addition, the present invention provides the purposes of the antibody of the engineering calcitonin gene-related peptide (CGRP) of people or its antigen-binding fragment what treatment osteo-arthritic pain.本發明提供了人的工程降鈣素基因相關肽(CGRP)抗體或其抗原結合片段。此外,本發明提供了人的工程降鈣素基因相關肽(CGRP)的抗體或其抗原結合片段用於治療骨關節炎疼痛的用途。