Nai-Kong V. Cheung,Mahiuddin Ahmed,Richard J. OReilly,Dimiter V. Tassev,Qi Zhao
申请号：
US14631211
公开号：
US20160152725A1
申请日:
2015.02.25
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Antigen-binding proteins specific for HLA-A2-restricted Wilms tumor 1 peptide are disclosed. The antigen-binding proteins encompass antibodies in a variety of forms, including full-length antibodies, substantially intact antibodies, Fab fragments, F(ab′)2 fragments, and single chain Fv (scFv) fragments, as well as chimeric antigen receptors. Fusion proteins, such as scFv fusions with immunoglobulin or T-cell receptor domains, incorporating the antigen-binding proteins are provided. Methods of using the antigen-binding proteins in the treatment of hyperproliferative diseases such as cancer are also disclosed.
