The invention provides a human engineering calcitonin gene-related peptide (CGRP) antibody or an antigen binding fragment thereof. In addition, the invention provides the use of antibodies or antigen binding fragments of human engineering calcitonin gene-related peptide (CGRP) for the treatment of osteoarthritis pain.本發明提供了人的工程降鈣素基因相關肽(CGRP)抗體或其抗原結合片段。此外,本發明提供了人的工程降鈣素基因相關肽(CGRP)的抗體或其抗原結合片段用於治療骨關節炎疼痛的用途。