ANTIGEN-BINDING PROTEIN THAT RECOGNIZES MAGE-A4-DERIVED PEPTIDE

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专利权人:

MIE UNIVERSITY

发明人:

Hiroshi SHIKU,Yasushi AKAHORI,Yuya KATO,Yoshihiro MIYAHARA

申请号：

US16619212

公开号：

US20200276237A1

申请日:

2018.06.05

申请国别(地区):

US

年份:

2020

代理人:

摘要：

CAR-T cells for cancer therapy are provided with an antibody that recognizes the MAGE-A4-derived-peptide/HLA-A2 complex. The antibody includes the VH amino acid sequence of SEQ ID NO: 36 and the VL amino acid sequence of SEQ ID NO: 38. The antibody preferably is provided with the amino acid sequence of SEQ ID NO: 32. Such CAR-T cells can be used in CAR infusion therapy in which a cancer-specific intracellular antigen is used.

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