PROBLEM TO BE SOLVED: To provide a novel 2-fluorophenyl propionic acid derivative avoiding adverse reactions such as gastrointestinal disorder and exhibiting excellent anti-inflammatory and analgesic actions.SOLUTION: The 2-fluorophenyl propionic acid derivative is represented by formula (I), and a pharmaceutically acceptable salt thereof is also provided. In the formula, R1 is a hydrogen atom, a halogen atom or a substituted or unsubstituted phenyl group X is -CH2-, -NH-, -O- or -S- Y is, in particular, a group wherein Z1 is -CO-, -CH(OH)- or -CH2- and n is an integer of 1 or 2.COPYRIGHT: (C)2013,JPO&INPIT【課題】胃腸障害等の副作用を回避すると共に、優れた抗炎症・鎮痛作用を有する新規な2-フルオロフェニルプロピオン酸誘導体の提供。【解決手段】式(I)で示される2-フルオロフェニルプロピオン酸誘導体又はその薬理学的に許容される塩。[式中、R1は、水素原子、ハロゲン原子又は置換若しくは非置換フェニル基を表し、Xは、-CH2-、-NH-、-O-、又は-S-を表し、Yは、特に、基:(基中、Z1は、-CO-、-CH(OH)-、又は-CH2-を表し、nは1又は2の整数を表す)。]【選択図】なし
