SIMONA M. CECCARELLI,RAVI JAGASIA,ROLAND JAKOL-ROETNE,JENS PETERS,JUERGEN UWE - WICHMANN
申请号：
ARP130104296
公开号：
AR093576A1
申请日:
2013.11.21
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
This document refers to general formula (1) and (2) compounds for the treatment of neurodegenerative and neuropsychiatric diseases. These compounds can be used to treat or prevent schizophrenia, OCD, depression, bipolar disorder, anxiety, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, Post traumatic stress disorder, panic Parkinson's disease, dementia, Alzheimer's disease, mild cognitive impairment,Cognitive impairment caused by chemotherapyDown's syndrome, autism spectrum disorder, hearing loss, darkness, espinosavera anoxia, Ames transverse sclerosis, multiple sclerosis, Huntington's disease, disorders caused by ICTY and radiation therapy, chronic stress, optic neuropathy or macular degeneration Or abuse of neuroactive drugs such as alcohol, opiates, methamphetamine, fenpropadine and cocaine. Claim 1: it is composed of formula R1 or (2), wherein R1 is hydrogen, low tar, low oxygen, halogen, or (ch832222) c83322 - low oxygen, or (ch832222) 8322； (n (ch832323) 83222o (ch832222) - morpholinior；R¹ is hydrogen, lower alkyl, lower alkoxy, halogen, O (CH₂) ₂-lower alkoxy, O (CH₂) ₂N (CH₃) ₂ or O (CH₂) -morpholinyl, with the proviso that both R¹ and R¹ are simultaneously hydrogen , although only one of R¹ and R¹ is lower alkyl, lower alkoxy, halogen, O (CH₂) ₂-lower alkoxy, O (CH₂) ₂N (CH₃) ₂ or O (CH₂) -morpholinyl； Het is a heteroaryl group of 5 or 6 elements, in which the heteroatoms are selected from N, O or S； X is -CRR-,-CRR-NR-C (O) --CH832222---CH -S (O) -CH₂-O- or -CH₂-CRR-；R / R are, independently, hydrogen, lower alkyl, hydroxy or phenyl, or R and R can form together with the carbon atom to which a cyclopropyl ring is attached； R² is lower alkyl, -C (O) O-lower alkyl, C₃₋₆ cycloalkyl optionally substituted with lower alkyl or = O, bridged cyclohexyl or C₃₋₆ cycloalkenyl,O is a heteromorphic group composed of five elements. Heteromorphic atoms are selected from n or s, and can be replaced by one or more lower tar, pyrid
