12352m65672n87842a992b1010A method of treating leukemia in a mammal by administering a solid dispersion comprising an amorphous thienotriazolodiazepine compound of the Formula (1) wherein R is alkyl having a carbon number of 1 4 R is a hydrogen atom a halogen atom or alkyl having a carbon number of 1 4 optionally substituted by a halogen atom or a hydroxyl group R is a halogen atom phenyl optionally substituted by a halogen atom alkyl having a carbon number of 1 4 alkoxy having a carbon number of 1 4 or cyano NR (CH) R wherein R is a hydrogen atom or alkyl having a carbon number of 1 4 m is an integer of 0 4 and R is phenyl or pyridyl optionally substituted by a halogen atom or NR CO (CH) R wherein R is a hydrogen atom or alkyl having a carbon number of 1 4 n is an integer of 0 2 and R is phenyl or pyridyl optionally substituted by a halogen atom and R is (CH) CO NH R wherein a is an integer of 1 4 and R is alkyl having a carbon number of 1 4 hydroxyalkyl having a carbon number of 1 4 alkoxy having a carbon number of 1 4 or phenyl or pyridyl optionally substituted by alkyl having a carbon number of 1 4 alkoxy having a carbon number of 1 4 amino or a hydroxyl group or (CH) COOR wherein b is an integer of 1 4 and R is alkyl having a carbon number of 1 4 or a pharmaceutically acceptable salt thereof or a hydrate or solvate thereof.
