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Heterocyclic sulfone RORγ modulators
专利权人:
BRISTOL-MYERS SQUIBB COMPANY
发明人:
Jingwu Duan,T. G. Murali Dhar,Bin Jiang,Ananta Karmakar,Arun Kumar Gupta,Zhonghui Lu
申请号:
US15109727
公开号:
US09637455B2
申请日:
2015.01.05
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Described are RORγ modulators of the formula (I), [INSERT CHEMICAL STRUCTURE HERE] or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
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