A compound of the formula (1): ** Formula ** or an N-oxide, hydrate, solvate, pharmaceutically acceptable salt thereof, or a racemic or chimemic mixture, diastereomer, enantiomer or tautomer thereof, wherein T is NH2 or OH； A is arylene, which is optionally substituted； and X is where Y>； = N, n1>； = 1 and Z1 is selected from the group consisting of R12-OC (O) -N (R2), (C1-C6 hydrocarbyl) -O- (C1 hydrocarbyl -C6) -OC (O) -N (R2) -, (C1-C6 hydrocarbyl) -OC (O) NR2) - or R16-OC (O) -N (R2) -, in which R16 20 is selected from the group consisting of (hydrocarbyl C1-C6) -, Ar- (hydrocarbyl C1-C2) -, Het- (hydrocarbyl C1-C2) -, Hca- (hydrocarbyl C0-C2) - or Cak- (hydrocarbyl C0-C2) -； wherein each R2 is independently selected from the group consisting of hydrogen, (C1-C5 alkyl) -, Hca- (C0-C4 alkyl) -, Cak- (C0-C4 alkyl) -, R14-CO-, R14 -SO2-, R14-CO-NH- and R14-CO-O-, wherein each alkyl is optionally substituted； each R12 is independently selected from the group consisting of (C1-C6 hydrocarbyl) -, Ar- (C1-C6 hydrocarbyl) -, Het- (C1-C6 hydrocarbyl) -, Hca- (C0-C6 hydrocarbyl) -, Cak- (C0-C6 hydrocarbyl) - optionally substituted； and each R14 is independently selected from the group consisting of Ar- e (C1-C6 hydrocarbyl) - optionally substituted； wherein any moiety (C1-C6 hydrocarbyl) - is optionally substituted, and each Ar is independently an optionally substituted aryl, each Het is independently an optionally substituted heteroaryl, each Hca is independently an optionally substituted heterocycloalkyl, and each Cak is independently a cycloalkyl optionally substituted.Un compuesto de la fórmula (1):**Fórmula** o un N-óxido, hidrato, solvato, sal farmacéuticamente aceptable del mismo, o una mezcla racémica o escalémica, diastereómero, enantiómero o tautómero del mismo, en el que T es NH2 u OH； A es arileno, que está opcionalmente sustituido； y X es en el que Y >；= N, n1 >；= 1 y Z1 se selecciona de entre el grupo que consiste en R12-O-C(O)-N(R2), (hidrocarbilo C
