Monoclonal antibodies are provided that selectively bind human hepcidin- 25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.本發明提供單株抗體,該等抗體選擇性結合人類海帕西啶(hepcidin)-25,且特徵為對人類海帕西啶-25具有高親和力及具有強烈人類成熟海帕西啶中和性質。本發明之抗體在治療上適用於增加人類血清鐵含量、網狀血球計數、紅血球計數、血紅素及/或血球比容,且適用於治療及診斷人類個體成熟海帕西啶促進之病症(諸如貧血)。(無元件符號說明書)
