PROBLEM TO BE SOLVED: To provide a complex having water solubility and cell affinity for facilitating the introduction of carborane used for a boron-neutron capture therapy into a living body, and to provide a method for preparing the complex.SOLUTION: The complex is obtained by allowing &beta-1,3-glucan of a natural polysaccharide to include the carborane. The method for preparing the complex includes a step for mixing the &beta-1,3-glucan and the carborane in a polar solvent solution, and maturing the product by adding water. Schizophyllan as the &beta-1,3-glucan and m-carborane as the carborane are preferably used.COPYRIGHT: (C)2008,JPO&INPIT【課題】ホウ素中性子捕捉療法に使用されるカルボランを生体内へ導入しやすくするための、水溶性かつ細胞親和性のある複合体及びその調製方法の提供。【解決手段】天然多糖のβ-1,3-グルカン内にカルボランを包接させた複合体。β-1,3-グルカンおよびカルボランを極性溶媒溶液中で混合し、水を加えて熟成する工程を含む、複合体の調製方法。β-1,3-グルカンとしてシゾフィランが、カルボランとしてm-カルボランが好適に使用できる。【選択図】図8
