As for this invention the peptide which can continue activity as the antagonist for substance P over long haul is offered. Consists of (c) the peptide which consists of part arrangement, the empty to continue activity as the antagonist for substance P, control activity and inflammation control activity over long haul painfully it is possible the peptide which is selected, 6 - 11 amino acids which it consists of (a) the peptide which consists of part arrangement, (c) Ala-Tyr-Gln-Leu-Glu-His-Thr-Phe-Gln-DTrp-Leu-Leu-NH2, and (d) include Thr-Phe-Gln-DTrp-Leu-Leu-NH2 of C end at least 6 - 11 amino acids which (a) Ala-Tyr-Gln-Leu-Glu-His-Thr-DTrp-Gln-Gly-Leu-Leu-NH2, (b) include Thr-DTrp-Gln-Gly-Leu-Leu-NH2 of C end at least, continue, continue.本発明はサブスタンスPに対するアンタゴニストとしての活性を長時間にわたり持続することができるペプチドを提供する。(a) Ala-Tyr-Gln-Leu-Glu-His-Thr-DTrp-Gln-Gly-Leu-Leu-NH2、(b) C末端のThr-DTrp-Gln-Gly-Leu-Leu-NH2を少なくとも含む、連続した6~11個のアミノ酸からなる(a)の部分配列からなるペプチド、(c) Ala-Tyr-Gln-Leu-Glu-His-Thr-Phe-Gln-DTrp-Leu-Leu-NH2、及び(d) C末端のThr-Phe-Gln-DTrp-Leu-Leu-NH2を少なくとも含む、連続した6~11個のアミノ酸からなる(c)の部分配列からなるペプチド、から選択されるペプチドは、サブスタンスPに対するアンタゴニストとしての活性、疼痛抑制活性、炎症抑制活性を長時間にわたり持続することができる。
