A target binding member that binds to IL-25, comprising an antibody VL domain comprising Kabat CDR 1-3 as set forth as residues 24-34 (SEQ ID NO: 29)； 50-56 (SEQ ID NO: 30) and 89-97 (SEQ ID NO: 31), respectively, of SEQ ID NO: 15 and an antibody VH domain comprising SEQ ID NO: 1: Glu Val Gln Leu Val Glu Be Gly Wing Glu Val Lys Lys Pro Gly Wing Be Val Lys Val Be Cys Lys Wing Be Gly Tyr Be Phe Xa1 Xa2 Tyr Thr Met Asn Trp Val Arg Gln Wing Pro Gly Gln Arg Leu Glu Trp Xa3 Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe Lys Gly Arg Val Thr Leu Thr Xa4 Asp Thr Ser Ala Ser Thr Ala Tyr Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys Ala Arg Glu Xa5 Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser where: Xa1 is Ser or Thr； Xa2 is Gly, Asp, Ala, Ser, Val, Asn, Lys, Tyr or Met； Xa3 is Met or Ile； Xa4 is Val or Arg； and Xa5 is Asp, Asn or Gly.Un miembro de unión a diana que se une a IL-25, que comprende un dominio VL de anticuerpo que comprende las CDR 1-3 de Kabat como se expone como los restos 24-34 (SEC ID Nº: 29)； 50-56 (SEC ID Nº: 30) y 89-97 (SEC ID Nº: 31), respectivamente, de SEC ID Nº: 15 y un dominio VH de anticuerpo que comprende SEC ID Nº: 1: Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Xa1 Xa2 Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Xa3 Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe Lys Gly Arg Val Thr Leu Thr Xa4 Asp Thr Ser Ala Ser Thr Ala Tyr Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys Ala Arg Glu Xa5 Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser en donde: Xa1 es Ser o Thr； Xa2 es Gly, Asp, Ala, Ser, Val, Asn, Lys, Tyr o Met； Xa3 es Met o Ile； Xa4 es Val o Arg； y Xa5 es Asp, Asn o Gly.
