597554 Disclosed is a glucagon-like peptide 2 (GLP-2) analogue represented by the general formula: R1-Z1-His-Gly-Glu-Gly-Ser-Phe-Ser-Asp-Glu-Leu-X11-Thr-Ile-Leu-Glu-X16-Leu-Ala-Ala- X20-Asp-Phe-Ile-X24-Trp-Leu-IIe-X28-Thr-Lys-Ile-Thr-Asp-Z2-R2, wherein: R1 is hydrogen, C1-4 alkyl, acetyl, formyl, benzoyl or trifluoroacetyl X11 is Leu or Phe X16 is Leu or Phe X20 is Ala or Ser X24 is Ala or Ser X28 is Ala or Ser R2 is NH2 or OH and Z1 and Z2 are independently absent or a peptide sequence of 1-10 amino acid units selected from the group consisting of Ala, Leu, Ser, Thr, Tyr, Asn, Gln, Asp, Glu, Lys, Arg, His, Met and Orn or a pharmaceutically acceptable salt thereof, such as: HGEGSFSDELLTILELLAASDFISWLISTKITDKKKKKK or HGEGSFSDELFTILEFLAASDFISWLISTKITDKKKKKK or HGEGSFSDELLTILELLAASDFISWLISTKITD or HGEGSFSDELFTILEFLAASDFISWLISTKITD or HGEGSFSDELLTILELLAAADFIAWLIATKITDKKKKKK.
