DAL FARRA, CLAUDE,DOMLOGE, NOUHA,BOTTO, JEAN-MARIE
申请号：
ES12708556
公开号：
ES2532545T3
申请日:
2012.01.30
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Peptide compound of the following general formula (I): R1- (AA) n- X1- X2- X3 -Asp-Leu-Lys-Lys-X4-X5 - (AA) p-R2 in which, X1 represents an asparagine, a serine, a glutamine or any amino acid, X2 represents a serine, a threonine, a cysteine or any amino acid, X3 represents an arginine, a lysine, a histidine or any amino acid, X4 represents a serine, a tyrosine, a threonine or any amino acid , X5 represents a phenylalanine, a proline, alanine, a valine or any amino acid, AA represents any one amino acid, and p and n are integers between 0 and 2, R1 represents the primary amine function of the N-terminal amino acid, -NH2, in the that one of the two hydrogen atoms may be substituted by a saturated or unsaturated C1 to C30 alkyl chain, or by an aromatic group of the benzoyl, tosyl or benzyloxycarbonyl type, R2 represents the hydroxyl group of the amino acid carboxyl function C-ter minal, - OH, wherein the hydrogen atom may be substituted by a C1 to C30 alkyl chain, or an NH2, NHY or NYY group, in which Y represents a C1 to C4 alkyl chain, said sequence of formula general (I) being constituted by 4 to 13 amino acid residues, characterized in that it corresponds to one of the following formulas: (SEQ ID No. 1) Ser-Cys-Arg-Asp-Leu-Lys-Lys-Thr-NH2 (SEC ID n ° 2) Asn - Ser - Ser - Lys - Asp - Leu - Lys - Lys - Phe - Val - Ala - NH2 (SEQ ID n ° 3) Cys - Lys - Asp - Leu - Lys - Lys - Ser - Phe (SEQ ID No. 4) Gln - Thr - Arg - Asp - Leu - Lys - Lys - Ser - Pro - Lys - Val- NH2 (SEQ ID No. 5) Asn - Lys - Asp - Leu - Lys - Lys - Pro - Met (SEQ ID No. 6) His - Asp - Leu - Lys - Lys - Tyr - NH2 (SEQ ID No. 7) Asp - Leu - Lys - Lys - NH2Compuesto peptídico de formula general siguiente (I): R1- (AA)n- X1- X2- X3 -Asp - Leu - Lys - Lys - X4 - X5 - (AA)p - R2 en la cual, X1 representa una asparagina, una serina, una glutamina o cualquier aminoácido, X2 representa una serina, una treonina, una cisteína o cualquier aminoácido, X3 representa una arginina, una lisina, una histidina o cualq
