Bruce M. Spiegelman,Jang Hyun Choi,Shingo Kajimura,Alexander Banks
申请号：
US13522736
公开号：
US20130019326A1
申请日:
2011.01.20
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides methods and compositions for selectively promoting anti-metabolic disorder activity over classical PPAR gamma activation through modulation of PPAR gamma phosphorylation (e.g., Ser-273 phosphorylation of murine peroxisome proliferator activated receptor gamma (PPAR gamma) 2 or a corresponding serine residue in a murine PPAR gamma 2 homolog, including a human). Also provided are methods for preventing, treating, or predictiving responsiveness of therapies for metabolic disorders in a subject through selective inhibition of such PPAR gamma phosphorylation. Further provided are methods for identifying compounds that are capable of modulating such PPAR gamma phosphorylation.
