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FLAVIVIRUS HOST-RANGE MUTATIONS AND USES THEREOF
专利权人:
Dennis T. Brown;Raquel Hernandez
发明人:
Dennis T. Brown,Raquel Hernandez
申请号:
US13173895
公开号:
US20120003255A1
申请日:
2011.06.30
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Methods and compositions concerning mutant flaviviruses with host-range phenotypes are provided. Nucleotide sequences that encode mutant flavivirus proteins are also provided. In certain aspects, viruses comprising these sequences display reduced replication in mammalian cells. In further aspects of the invention, flavivirus vaccine compositions and methods for vaccination against flavivirus infection are provided.
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