THE GOVERNMENT OF THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE CRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
BLANEY, JOSEPH E.,WHITEHEAD, STEPHEN S.,MURPHY, BRIAN R.,HANLEY, KATHRYN A.,LAI, CHING-JUH
申请号：
CA2966716
公开号：
CA2966716C
申请日:
2002.05.22
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
This invention provides flavivirus having a viral genome modified by the introduction of one or more mutations. The flavivirus may be attenuated and may have a phenotype that is temperature sensitivity, host-cell restriction or host-cell adaptation for improved replication. A menu of mutations was developed that is useful in fine-tuning attenuation and growth characteristics of dengue virus vaccines.
