Multi-substituted selective androgen receptor modulators and methods of use thereof

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专利权人:

UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION

发明人:

DALTON, JAMES T.,MILLER, DUANE D.,HE, YALI,STEINER, MITCHELL S.,HWANG, DONG JIN,CHEN, JIYUN

申请号：

ES10010264

公开号：

ES2528764T3

申请日:

2003.02.24

申请国别(地区):

ES

年份:

2015

代理人:

摘要：

A compound represented by the structure of formula IV: ** Formula ** wherein X is O； G is O or S； T is OH, OR, NHCOCH3 or NHCOR； R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3； aryl, phenyl, halogen, alkenyl or OH； R1 is CH3, CH2F, CHF2, CF3, CH2CH3 or CF2CF3； R3 is F, Cl, Br, I, CN, NO2, COR, COOH, CONHR, CF3, Sn (R) 3, or R3 together with the benzene ring to which it is attached forms a condensed ring system represented by the structure: ** Formula ** Z is NO2, CN, COR, COOH or CONHR； Y is CF3, F, Br, Cl, I, CN or Sn (R) 3； Q is alkyl, halogen, CF3, CN, C (R) 3, Sn (R) 3, N (R) 2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR, NHSO2CH3, NHSO2R, OH, OR, COR, OCOR, OSO2R, SO2R or SR； p 'is an integer from 1-4； and m is an integer of 1-3.Un compuesto representado por la estructura de fórmula IV:**Fórmula** en donde X es O； G es O o S； T es OH, OR, NHCOCH3 o NHCOR； R es alquilo, haloalquilo, dihaloalquilo, trihaloalquilo, CH2F, CHF2, CF3, CF2CF3； arilo, fenilo, halógeno, alquenilo o OH； R1 es CH3, CH2F, CHF2, CF3, CH2CH3 o CF2CF3； R3 es F, Cl, Br, I, CN, NO2, COR, COOH, CONHR, CF3, Sn(R)3, o R3 junto con el anillo de benceno al que está unido forma un sistema anular condensado representado por la estructura:**Fórmula** Z es NO2, CN, COR, COOH o CONHR； Y es CF3, F, Br, Cl, I, CN o Sn(R)3； Q es alquilo, halógeno, CF3, CN, C(R)3, Sn(R)3, N(R)2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR, NHSO2CH3, NHSO2R, OH, OR, COR, OCOR, OSO2R, SO2R o SR； p' es un número entero de 1-4； y m es un número entero de 1-3.

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