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Multi-substituted selective androgen receptor modulators and methods of use thereof
专利权人:
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
发明人:
DALTON, JAMES T.,MILLER, DUANE D.,HE, YALI,STEINER, MITCHELL S.,HWANG, DONG JIN,CHEN, JIYUN
申请号:
ES10010264
公开号:
ES2528764T3
申请日:
2003.02.24
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound represented by the structure of formula IV: ** Formula ** wherein X is O; G is O or S; T is OH, OR, NHCOCH3 or NHCOR; R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3; aryl, phenyl, halogen, alkenyl or OH; R1 is CH3, CH2F, CHF2, CF3, CH2CH3 or CF2CF3; R3 is F, Cl, Br, I, CN, NO2, COR, COOH, CONHR, CF3, Sn (R) 3, or R3 together with the benzene ring to which it is attached forms a condensed ring system represented by the structure: ** Formula ** Z is NO2, CN, COR, COOH or CONHR; Y is CF3, F, Br, Cl, I, CN or Sn (R) 3; Q is alkyl, halogen, CF3, CN, C (R) 3, Sn (R) 3, N (R) 2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR, NHSO2CH3, NHSO2R, OH, OR, COR, OCOR, OSO2R, SO2R or SR; p 'is an integer from 1-4; and m is an integer of 1-3.Un compuesto representado por la estructura de fórmula IV:**Fórmula** en donde X es O; G es O o S; T es OH, OR, NHCOCH3 o NHCOR; R es alquilo, haloalquilo, dihaloalquilo, trihaloalquilo, CH2F, CHF2, CF3, CF2CF3; arilo, fenilo, halógeno, alquenilo o OH; R1 es CH3, CH2F, CHF2, CF3, CH2CH3 o CF2CF3; R3 es F, Cl, Br, I, CN, NO2, COR, COOH, CONHR, CF3, Sn(R)3, o R3 junto con el anillo de benceno al que está unido forma un sistema anular condensado representado por la estructura:**Fórmula** Z es NO2, CN, COR, COOH o CONHR; Y es CF3, F, Br, Cl, I, CN o Sn(R)3; Q es alquilo, halógeno, CF3, CN, C(R)3, Sn(R)3, N(R)2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR, NHSO2CH3, NHSO2R, OH, OR, COR, OCOR, OSO2R, SO2R o SR; p' es un número entero de 1-4; y m es un número entero de 1-3.
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