WANG XILU,SOUERS ANDREW,CATRON NATHANIEL,TAO ZHI,FU - SULLIVAN GERARD
申请号：
ARP110101806
公开号：
AR081552A1
申请日:
2011.05.26
申请国别(地区):
AR
年份:
2012
代理人:
摘要：
Compounds that inhibit the activity of anti apoptotic Protein bcl-2, compositions containing such compounds and Methods for treating diseases in which Express Anti apoptotic Protein bcl-2.Claim 1: wherein is a compound of formula (1), (Formula 2), (3) or formula where N C (A2 A1 or A2)； r1 is H, OR1, SR1, S (OR) so2r1, R1, R1, C (o) C (o) OR1, OC (or) nhr1 n, R1 (R1) 2, C (o) C (o) n nhr1, NHC 2 (R1), (OR), (OR) nr1c R1, R1, NHC (OR) OR1, nr1c (OR) OR1, NHC (NH2), NHC (OR) nhr1, NHC (OR) N 2 (R1), (OR) nr1c nhr1, nr1c (o) n (R1) 2, so2nh2, so2nhr1, so2n (R1) 2, nhso2r1, nr1so2r1, nhso2nhr1, nhso2n (R1) 2Nr1so2nhr1, nr1so2n (R1) 2, C (or nhnoh), C (o) C (o) nhnor1, nhso2r1, C (NH) NH2, nhr1 C (NH), C (NH) 2 nhso2nhr1 nhso2n (R1), (CH3) n (CH3) so2n R1, R1 (CH3) f, CL, BR, I, CN, NO2, no, o, h, C (o) CH (chnoh, noch3), NF3, C (o) - C (o) C (o) NH2 or or1a； B1 is H, OR1, SR1, R1, R1 s (o) so2r1, R1, C (o) C (o) OR1, OC (R1), nhr1, n (R1) 2, C (o) C (o) n nhr1, NHC 2 (R1), (OR), (OR) nr1c R1, R1, NHC (OR) OR1, nr1c (OR) OR1, NHC (NH2), (OR) nhr1, NHCNHC (o) n (R1) (OR) 2, nr1c nhr1, nr1c (o) n (R1) 2, so2nh2, so2nhr1, so2n (R1) 2, nhso2r1, nr1so2r1, nhso2nhr1, nhso2n (R1) 2, nr1so2nhr1, nr1so2n (R1) 2, C (or nhnoh, (c) or nhnor1), C (o) nhso2r1, C (NH) NH2, nhr1 C (NH), C (NH) 2 nhso2nhr1 nhso2n (R1), (CH3) n (CH3) so2n R1, R1 (CH3), F, CL, BR, I, CN, NO2, no, oh (c, h, o) chnoh, C H (noch3), NF3, C (o) - C (o) C (o) NH2 or or1a is h； D1, R1, OR1, SR1, S (OR) so2r1, R1, R1, C (o) C (o) OR1,OC (OR) nhr1 n, R1 (R1) 2, C (o) C (o) n nhr1, NHC 2 (R1), (OR), (OR) nr1c R1, R1, NHC (OR) OR1, nr1c (OR) OR1, NHC (NH2), NHC (OR) nhr1, NHC (o) n (R1) (OR) 2, nr1c nhr1, nr1c (o) n (R1) 2, so2nh2, so2nhr1, so2n (R1) 2, nhso2r1, nr1so2r1, nhso2nhr1, nhso2n (R1) 2, nr1so2nhr1, nr1so2n (R1) 2, C (OR) nhnoh, nhnor1, C (o) C (o) nhso2r1, C (C (NH2, NH) Nhr1 NH), C (NH) 2 nhso2nhr1 nhso2n (R1), (CH3) n (CH3) so2n R1, R1 (CH3), F, CL, BR, I, CN, NO2, no, Oh,C (o) h, chnoh, CH (noch3), NF3,
