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SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES
专利权人:
ГРЮНЕНТАЛЬ ГМБХ (DE)
发明人:
НОЛЬТЕ Берт (DE),ШРЁДЕР Вольфганг (DE),ЛИНЦ Клаус (DE),ЭНГЛЬБЕРГЕР Вернер (DE),ШИК Ханс (DE),ГРАУНБАУМ Хайнц (DE),РОЛОФФ Биргит (DE),ОЦЕГОВСКИ Зигрид (DE),БАЛИНТ Йожев (DE),ЗОННЕНШАЙН Хельмут (DE)
申请号:
RU2012120387/04
公开号:
RU2012120387A
申请日:
2012.05.17
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. The compound of General formula (1) where Y, Y ', Y, Y', Y, Y ', Y and Y' in each case, independently from each other, are selected from the group consisting of -H, -F, -Cl, -Br , -I, -CN, -NO, -CHO, -R, -C (= O) R, -C (= O) H, -C (= O) -OH, -C (= O) OR, - C (= O) NH, -C (= O) NHR, C (= O) N (R), -OH, -OR, -OC (= O) H, -OC (= O) R, -OC ( = O) OR, -OC (= O) NHR, -OC (= O) N (R), -SH, -SR, -SOH, -S (= O) -R, -S (= O) NH, -NH, -NHR, N (R), -N (R), -N (R) O, -NHC (= O) R, -NHC (= O) OR, -NHC (= O) NH, NHC ( = O) NHR and -NHC (= O) N (R); preferably in each case, independently from each other, selected from the group consisting of —H, —F, —Cl, —CN, and —C-aliphate; or Y and Y ', or Y and Y', or Y and Y ', or Y and Y' together mean = O; Q means -R, -C (= O) -R, -C (= O) OR, -C (= O) NHR, —C (= O) N (R) or —C (= NH) —R; R in each case independently means —C-aliphate, —C-cycloaliphate, aryl, -heteroaryl, —C-aliphate- C-cycloaliphate, -C-aliphate-aryl, -C-aliphate-heteroaryl, -C-cycloaliphate-C-aliphate, -C-cycloaliphate-aryl or -C-cycloaliphate-heteroaryl; R and R, independently of one another, mean - H or -R; or R and R together form a ring and are —CHCHOCHCH—, CHCHNRCHCH— or - (CH) -; indicating that R and Roba at the same time do not mean -H; R means -R; R in each case independently means -H, -R or -C (= O) R; n means an integer from 0 to 12; X means -O-, - S- or -NR-; R means -H, -R, -S (= O) R, -C (= O) R, -C (= O) OR, -C (= O) NH, -C (= O) NHR or -C (= O) N (R); R is -H, -R, -C (= O) H, -C (= O) R, -C (= O) OH, -C (= O ) OR, -C (= O) NH, C (= O) NHR, -C (= O) N (R), -S (= O) -R, -S (= O) -OR, -S ( = O) -NH, S (= O) -NHR or -S (= O) -N (R); or R and R together form a ring and mean - (CH) -, -CHCHOCHCH- or -CHCHNRCHCH-; indicating that if X is —O— and at the same time n is 0, then R is not —H; wherein the “aliphat” in each case is branched or unbranched, saturated or mono- or multiply unsaturated, unsubstituted or mono- or multiply substituted , an aliphatic hydrocar
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