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SARM COMPOUNDS AND WAYS OF THEIR APPLICATION
专利权人:
ЮНИВЕРСИТИ ОФ ТЕННЕССИ РИСЕРЧ ФАУНДЕЙШН (US)
发明人:
ДОЛТОН Джеймс Т. (US),МИЛЛЕР Дуэйн Д. (US),КИРБИ Джеффри (US)
申请号:
RU2012144842/04
公开号:
RU2012144842A
申请日:
2011.03.22
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of influencing the carcass composition in animals, comprising administering a compound of formula IIIA: wherein Z is NO, CN, Cl, F, Br, I, H, COR, COOH or CONHR; Y is CF, alkoxy, alkyl, hydroxyalkyl, alkylaldehyde , formyl, H, F, Br, Cl, I, CN or Sn (R); R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CHF, CHF, CF, CFCF, aryl, phenyl, halogen, alkenyl or OH; R is H , F, Cl, Br, I, CH, CF, OH, CN, NO, NHCOCH, NHCOCF, NHCOR, alkyl, arylalkyl, OR, NH, NHR, N (R), SR; R is H, F, Cl, Br , I, CN, NO, COR, COOH, CONHR, CF, Sn (R); Q is H, alkyl, halogen, CF, CN, C (R), Sn (R), N (R), NHCOCH, NHCOCF , NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH, NHCSCF, NHCSR, NHSOCH, NHSOR, OH, OR, COR, OCOR, OSOR, SOR, SR; n - integer number from 1 to 4; and m is an integer from 1 to 3; or an isomer thereof, a pharmaceutically acceptable salt, pharmaceutical, crystal, N-oxide, hydrate, or any combination thereof. 2. The method according to claim 1, wherein the animals are driven animals, beef cattle or fattening cattle. The method according to claim 1, wherein the carcass composition is exposed by increasing lean mass, reducing fat mass and / or reducing the percentage of fat mass. The method according to claim 1, in which the effect on the composition of the carcass includes an increase in growth rates in animals. The method of claim 1, wherein the method comprises feeding the animals such daily food that contains a compound of formula IIIA. The method of claim 1, wherein the method comprises feeding the animal such daily food that contains a compound of formula IIIA and a β-adrenergic agonist. The method of claim 6, wherein the β-adrenergic agonist is ractopamine hydrochloride (Paylean®). The method according to claim 1, wherein the compound is a compound of formula I: wherein Q is alkyl, F, Cl, Br, I, CF, CN, C (R), Sn (R), N (R), NHCOCH, NHCOCF, NHCOR , NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH, NHCSCF, NHCSR, NHSOCH, NHSOR, OR, COR, OCOR1. Способ воздействия на состав ту
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