JAESCHKE GEORG,LINDEMANN LOTHAR,RICCI ANTONIO,RUEHER DANIEL,STADLER HEINZ,VIEIRA ERIC
申请号：
NZ62189412
公开号：
NZ621894A
申请日:
2012.10.04
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
The disclosure relates to ethynyl derivatives of formula (I) wherein the unspecified moieties are disclosed within the specification, or a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. The disclose also relates to their use in the treatment of or prevention of schizophrenia, cognitive diseases, fragile X syndrome or autism. Example compounds include: 1-[6-(4-Fluoro-phenylethynyl)-pyridin-3-yl]-3,4,4-trimethyl-imidazolidin-2-one 1-[6-(3-Fluoro-phenylethynyl)-pyridin-3-yl]-3,4,4-trimethyl-imidazolidin-2-one 2-[6-(3-Fluoro-phenylethynyl)-pyridin-3-yl]-1,5,5-trimethyl-5 pyrazolidin-3-one 2-[6-(2,5-Difluoro-phenylethynyl)-pyridin-3-yl]-1,5,5-trimethyl-pyrazolidin-3-one 4,4-Dimethyl-1-(6-phenylethynyl-pyridin-3-yl)-pyrrolidin-2-one 6,6-Dimethyl-3-(6-phenylethynyl-pyridin-3-yl)-[1,3]oxazinan-2-one.
