The present invention discloses a compound separated from Monascus-fermented rice, the preparation method and uses thereof. Specifically, the present invention discloses a compound represented by the Formula I, or a pharmaceutically acceptable salt thereof, wherein, R1 is selected from the group consisting of hydrogen, hydroxyl, C1-6 straight or branched alkoxyl, (II), (III) and (IV)； R2 is hydrogen or C1-6 alkyl； R3 is selected from the group consisting of hydrogen, hydroxyl and C1-6 straight or branched alkoxyl. The present invention further discloses a pharmaceutical composition containing the compound. The compound of the present invention has HMG-CoA reductase inhibition effects.本發明屬於醫藥化工領域，係關於一種自紅麯中分離之化合物、其製備方法及用途。詳言之，式I所示之化合物或其醫藥學上可接受之鹽，其中，R1選自氫、羥基、C1-6直鏈或支鏈烷氧基、及；R2為氫或C1-6烷基；R3選自氫、羥基及C1-6直鏈或支鏈烷氧基。本發明亦關於含有該化合物之醫藥組合物。本發明之化合物具有HMG-CoA還原酶抑制作用。
