A NEW CRYSTAL FORM OF ANTICANCER COMPOUND AND ITS PREPARATION METHODS AND USE THEREOF

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专利权人:

发明人:

YANG, BAOHAI,杨宝海,楊寶海,XIONG, LONG,熊龙,熊龍,YU, JUN,余 俊,余 俊

申请号：

TW104126056

公开号：

TW201706280A

申请日:

2015.08.11

申请国别(地区):

TW

年份:

2017

代理人:

摘要：

The present invention discloses a crystal form of an anticancer compound of (R) -3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[3-fluorophenyl -1-dimethylphosphine acyloxy-4-yl] pyridin-2-amine and its preparation method, which have the structural formula showing as formula I. The crystal form of present invention is stable, high purity, no hygroscopicity, high bioavailability and suitable for pharmaceutical preparation.本發明公開了一種抗癌化合物(R)-3-[1-(2,6-二氯-3-氟苯基)乙氧基]-5-[3-氟苯基-1-二甲基膦醯氧-4-基]吡啶-2-胺晶型及其製備方法,其結構式如式I所示。本發明晶型性質穩定,純度高,無吸濕性,生物利用度高,適合藥物製劑需求。

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