An apparatus and a method for crystallization and supercritical drying of a culture solution are provided. The apparatus for crystallization and supercritical drying of a culture solution is an apparatus, which dries a culture solution comprising a first solvent and a target material dissolved in the first solvent, so as to obtain the target material, and comprises: a high pressure vessel for accommodating the culture solution； a first supply part connected with the high pressure vessel so as to supply a second solvent to the high pressure vessel； a second supply part connected with the high pressure vessel so as to supply a third solvent to the high pressure vessel； a precooler which is arranged to be adjacent to the first supply part, and which precools the second solvent to be discharged from the first supply part； and a preheater which is arranged to be adjacent to the high pressure vessel, and which preheats the second solvent and the third solvent that are supplied to the high pressure vessel.The method for crystallization and supercritical drying of a culture solution is a method, which dries a culture solution comprising a first solvent and a target material dissolved in the first solvent, so as to obtain the target material, and comprises the steps of: replacing the first solvent with a second solvent in the culture solution so as to crystallize the target material； and phase-transferring the second solvent into a supercritical phase.L'invention concerne un appareil et un procédé de cristallisation et de séchage supercritique d'une solution de culture. L'appareil de cristallisation et de séchage supercritique d'une solution de culture est un appareil, lequel sèche une solution de culture comprenant un premier solvant et une substance cible dissoute dans le premier solvant de façon à obtenir la substance cible, et comprend : un récipient à haute pression destiné à recevoir la solution de culture ； une première partie d'alimentation reliée au récipient à ha
